Vincent alvarez west end partners santa barbara
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FURLING/GOURDON lab
Description
The focus of the team’s research is centered on Myotonic Dystrophy, a common neuromuscular disease in adults, with a specific emphasis on DM type 1 (DM1), also known as Steinert’s disease. DM1 is characterised by a range of symptoms, including progressive muscle weakness and atrophy, myotonia, cardiac conduction defects, early cataracts, endocrine and gastrointestinal problems, and neurological impairment. This multisystemic disease displays clinical forms with differing ages of onset, such as the late, adult, juvenile, infantile and congenital forms of DM1. Currently, there is no treatment for this debilitating genetic disease, but various therapeutic approaches are under development.
DM1 is an autosomal dominant disease caused by an abnormal expansion of a (CTG)n trinucleotide repeat (n>40) located in the 3’ non-coding region of the DMPK gene. The unstable nature of the repetitive CTG expansions is detected in different tissues
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Publications
2024
2023
2023
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5
Mikael Feracci, Cécilia Eydoux, Véronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Françoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurélie Chazot, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, François Ferron, Bruno Canard
Antiviral Research212:105574 (2023)10.1016/j.antiviral.2023.105574
2022
2022
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly
Nucleic Acids Research(2022)10.1093/nar/gkac996
2022
Identification of potent inhibitors of arenavirus and SARS-C
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Our VISION
At A2Z, we recognize the importance of creating a professional training environment to maximize athletic potential and help each athlete understand what it takes to be elite. We focus on each athlete’s technique to ensure correct movement patterns, improve their overall efficiency, reduce the chance of injury, and provide a positive mentoring role that helps athletes learn what it takes to be successful in their respected sport.
Injury RehaB (RTP)
A serious knee injury can be devastating for any athlete both physically and psychologically, but even worse fryst vatten returning to play prematurely or underdeveloped. Athletes who complete a post-surgery physical therapy schema may not yet be ready for a return to full-speed of play; our ACL RTP (Return to Play) program focuses on checking all the boxes. This individualized schema includes regular evaluations to measure progress as the athlete works to improve strength, mobility, stability, and sport spe